1
00:00:03,350 --> 00:00:01,790
in this article by Michael Levin and

2
00:00:05,150 --> 00:00:03,360
Wendy Bean the importance of tissue

3
00:00:07,130 --> 00:00:05,160
Remodeling and maintenance of proportion

4
00:00:09,169 --> 00:00:07,140
during organism-wide tissue scaling for

5
00:00:10,850 --> 00:00:09,179
regenerative medicine is discussed while

6
00:00:12,770 --> 00:00:10,860
it was known that making new cells alone

7
00:00:14,749 --> 00:00:12,780
was not enough for tissue regeneration

8
00:00:16,369 --> 00:00:14,759
it wasn't clear whether new cell

9
00:00:18,170 --> 00:00:16,379
production and remodeling were a

10
00:00:20,689 --> 00:00:18,180
separate or integrated process this

11
00:00:23,810 --> 00:00:20,699
study on planaria invited a specific ion

12
00:00:25,429 --> 00:00:23,820
transporter h plus K plus atpase that

13
00:00:27,650 --> 00:00:25,439
regulates tissue remodeling via

14
00:00:29,870 --> 00:00:27,660
apoptosis during regeneration the role

15
00:00:32,210 --> 00:00:29,880
of membrane depolarization calcium entry

16
00:00:33,889 --> 00:00:32,220
and apoptosis in shaping the tissues was

17
00:00:35,750 --> 00:00:33,899
also explored the study provides new

18
00:00:36,950 --> 00:00:35,760
genetic entry points into how remodeling

19
00:00:38,450 --> 00:00:36,960
events are coordinated with

20
00:00:40,130 --> 00:00:38,460
predetermined templates for shape

21
00:00:41,869 --> 00:00:40,140
determination the research shows that

22
00:00:43,729 --> 00:00:41,879
these ions play a key role in

23
00:00:45,350 --> 00:00:43,739
determining anatomical polarity and

24
00:00:47,389 --> 00:00:45,360
regulating shape determination and

25
00:00:49,549 --> 00:00:47,399
allometric scaling during regeneration

26
00:00:51,410 --> 00:00:49,559
the concept of morphallaxis was also

27
00:00:53,270 --> 00:00:51,420
discussed with the focus on the signals

28
00:00:55,069 --> 00:00:53,280
directing the scale and geometry of the

29
00:00:56,810 --> 00:00:55,079
processes during regeneration this can